RheOxTM Technology

RheOx is a bronchoscopic therapy that delivers non-thermal pulsed electric fields to the airways to reduce mucus-producing cells in patients with Chronic Bronchitis.

Mucus obstruction resulting in shortness of breath and cough

RheOx ablates mucus producing cells

Cells regenerate with fewer abnormal cells, therefore producing less mucus

RheOxTM

RheOx consists of a proprietary electrosurgical generator and a single-use catheter.

Non-Thermal, Controlled Energy Delivery

  • Pulsed electric fields target abnormal cells, leaving extracellular matrix intact
  • Rapid regeneration of epithelium1

User-Friendly Delivery

  • RheOx catheter is delivered through a bronchoscope by a single operator

Bronchial Rheoplasty Procedure

  1. Fernandez-Bussy et al. Histopathologic Results Post Bronchial Rheoplasty. ATS 2019, Dallas, TX.
  2. FastStats - Chronic Lower Respiratory Disease. Centers for Disease Control (CDC) / National Center for Health Statistics (NCHS) 2017; https://www.cdc.gov/nchs/fastats/copd.htm
  3. Criner, G. Chronic Bronchitis: The Case for an Unmet Medical Need. ERS 2017, Milan, Italy
  4. Health at a Glance: Europe (2012 and 2014 reports) http://www.oecd-ilibrary.org/social-issues-migration-health/health-at-a-glance-europe-2012_9789264183896-en
  5. Cerveri, et al, Variations in the prevalence across countries of Chronic Bronchitis and smoking habits in young adults; Eur Respir J 2001; 18: 85–92
  6. Kim et al. The Chronic Bronchitic Phenotype of COPD: An analysis of the COPD Gene Study CHEST 2011; 140(3):626–633
  7. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017. Available from: https://goldcopd.org.
  8. A. Valipour, et al. Bronchial Rheoplasty For Treatment of Chronic Bronchitis: 12 Month Results from a Multi-Center Study. Am J Respir Crit Care Med 2020; Vol. 202 Number 5.