Incidence & Prevalence

9 million people in the US and 15 million in Europe are living with Chronic Bronchitis2, 3, 4, 5

Chronic Bronchitis

Chronic Bronchitis develops after exposure to cigarette smoke, vaping, secondhand smoke, airborne chemicals, and other pollution and irritants. Long-term exposure causes chronic inflammation, excess mucus production, and persistent cough.

Exposure to cigarette smoke, vaping liquid, or pollutants

Production of mucus to expel irritants

Chronic inflammation causes more mucus production

Signs & Symptoms





COPD patients with Chronic Bronchitis have a reduced quality of life, worse respiratory symptoms, and a higher risk of exacerbations as compared to COPD patients without CB.6

64% worse

1.4x more
likely awakened
by cough6

Currently There Are

no treatment Options

for Chronic Bronchitis that directly target the cells that produce mucus.7

  1. Fernandez-Bussy et al. Histopathologic Results Post Bronchial Rheoplasty. ATS 2019, Dallas, TX.
  2. FastStats - Chronic Lower Respiratory Disease. Centers for Disease Control (CDC) / National Center for Health Statistics (NCHS) 2017;
  3. Criner, G. Chronic Bronchitis: The Case for an Unmet Medical Need. ERS 2017, Milan, Italy
  4. Health at a Glance: Europe (2012 and 2014 reports)
  5. Cerveri, et al, Variations in the prevalence across countries of Chronic Bronchitis and smoking habits in young adults; Eur Respir J 2001; 18: 85–92
  6. Kim et al. The Chronic Bronchitic Phenotype of COPD: An analysis of the COPD Gene Study CHEST 2011; 140(3):626–633
  7. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017. Available from:
  8. Valipour, A. et al. First-in-Human Results of Bronchial Rheoplasty: An endobronchial Treatment for Chronic Bronchitis. ATS 2019, Dallas, TX.